Ontology highlight
ABSTRACT:
SUBMITTER: Sogabe S
PROVIDER: S-EPMC5512123 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Sogabe Satoshi S Kamada Yusuke Y Miwa Masanori M Niida Ayumu A Sameshima Tomoya T Kamaura Masahiro M Yonemori Kazuko K Sasaki Shigekazu S Sakamoto Jun-Ichi JI Sakamoto Kotaro K
ACS medicinal chemistry letters 20170510 7
The Ras proteins play roles in cell differentiation, proliferation, and survival. Aberrant signaling through Ras-mediated pathways in tumor cells occurs as a result of several types of mutational damage, which most frequently affects the amino acids G12, G13, and Q61. Recently, KRpep-2d was identified as a K-Ras(G12D) selective inhibitory peptide against the G12D mutant of K-Ras, which is a key member of the Ras protein family and an attractive cancer therapeutic target. In this study, the cryst ...[more]