Ontology highlight
ABSTRACT:
SUBMITTER: Silva DG
PROVIDER: S-EPMC5512129 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20170627 7
The present work describes the synthesis of 22 new imidazopyridine analogues arising from medicinal chemistry optimization at different sites on the molecule. Seven and 12 compounds exhibited an in vitro EC<sub>50</sub> ≤ 1 μM against <i>Trypanosoma cruzi</i> (<i>T. cruzi</i>) and <i>Trypanosoma brucei</i> (<i>T. brucei</i>) parasites, respectively. Based on promising results of <i>in vitro</i> activity (EC<sub>50</sub> < 100 nM), cytotoxicity, metabolic stability, protein binding, and pharmacok ...[more]