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Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction.

ABSTRACT: Enhanced fetal ?-globin synthesis alleviates symptoms of ?-globinopathies such as sickle cell disease and ?-thalassemia, but current ?-globin-inducing drugs offer limited beneficial effects. We show here that lysine-specific demethylase 1 (LSD1) inhibition by RNAi in human erythroid cells or by the monoamine oxidase inhibitor tranylcypromine in human erythroid cells or ?-type globin-transgenic mice enhances ?-globin expression. LSD1 is thus a promising therapeutic target for ?-globin induction, and tranylcypromine may serve as a lead compound for the development of a new ?-globin inducer.

SUBMITTER: Shi L

PROVIDER: S-EPMC5512162 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction.

Shi Lihong L Cui Shuaiying S Engel James D JD Tanabe Osamu O

Nature medicine 20130217 3

Enhanced fetal γ-globin synthesis alleviates symptoms of β-globinopathies such as sickle cell disease and β-thalassemia, but current γ-globin-inducing drugs offer limited beneficial effects. We show here that lysine-specific demethylase 1 (LSD1) inhibition by RNAi in human erythroid cells or by the monoamine oxidase inhibitor tranylcypromine in human erythroid cells or β-type globin-transgenic mice enhances γ-globin expression. LSD1 is thus a promising therapeutic target for γ-globin induction, ...[more]

PMID: 23416702

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