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A Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate.

ABSTRACT: Here we report the identification of protein targets of chemopreventive phenethyl isothiocyanate (PEITC) via "click" chemistry in the A549 human lung cancer cell line, using a novel alkyne-tagged PEITC which was also found to show potent in vitro anticancer activity.

SUBMITTER: Fu Y 

PROVIDER: S-EPMC5512166 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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A Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate.

Fu Ying Y   Mi Lixin L   Sanda Miloslav M   Silverstein Shana S   Aggarwal Monika M   Wang Deyun D   Gupta Pankaj P   Goldman Radoslav R   Appella Daniel H DH   Chung Fung-Lung FL  

RSC advances 20140101 8

Here we report the identification of protein targets of chemopreventive phenethyl isothiocyanate (PEITC) via "click" chemistry in the A549 human lung cancer cell line, using a novel alkyne-tagged PEITC which was also found to show potent <i>in vitro</i> anticancer activity. ...[more]

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