Ontology highlight
ABSTRACT:
SUBMITTER: Egawa N
PROVIDER: S-EPMC5512301 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Egawa Naohiro N Shindo Akihiro A Liang Anna C AC Du Yang Y Xing Changhong C Lo Evan K EK Itoh Kanako K Kinoshita Hisanori H Maki Takakuni T Takahashi Ryosuke R Sudo Ryo R Spector Myron M Lok Josephine J Arai Ken K
Stem cells and development 20170524 14
Oligodendrocytes are generated from oligodendrocyte precursor cells (OPCs). Mechanisms of OPC differentiation have been extensively examined with two-dimensional cell culture systems. However, these cellular events may be more accurately represented using a three-dimensional (3D) model. In this study, we report the development of a novel 3D OPC culture system using gels composed of a mixture of collagen and hyaluronan, wherein cultured rat primary OPCs can proliferate and differentiate into olig ...[more]