Ontology highlight
ABSTRACT:
SUBMITTER: Wiemann P
PROVIDER: S-EPMC5512462 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Wiemann Philipp P Perevitsky Adi A Lim Fang Yun FY Shadkchan Yana Y Knox Benjamin P BP Landero Figueora Julio A JA Choera Tsokyi T Niu Mengyao M Steinberger Andrew J AJ Wüthrich Marcel M Idol Rachel A RA Klein Bruce S BS Dinauer Mary C MC Huttenlocher Anna A Osherov Nir N Keller Nancy P NP
Cell reports 20170501 5
The Fenton-chemistry-generating properties of copper ions are considered a potent phagolysosome defense against pathogenic microbes, yet our understanding of underlying host/microbe dynamics remains unclear. We address this issue in invasive aspergillosis and demonstrate that host and fungal responses inextricably connect copper and reactive oxygen intermediate (ROI) mechanisms. Loss of the copper-binding transcription factor AceA yields an Aspergillus fumigatus strain displaying increased sensi ...[more]