Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer.
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ABSTRACT:
SUBMITTER: Lin SC
PROVIDER: S-EPMC5512590 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
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Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer.
Lin Song-Chang SC Lee Yu-Chen YC Yu Guoyu G Cheng Chien-Jui CJ Zhou Xin X Chu Khoi K Murshed Monzur M Le Nhat-Tu NT Baseler Laura L Abe Jun-Ichi JI Fujiwara Keigi K deCrombrugghe Benoit B Logothetis Christopher J CJ Gallick Gary E GE Yu-Lee Li-Yuan LY Maity Sankar N SN Lin Sue-Hwa SH
Developmental cell 20170601 5
Prostate cancer (PCa) bone metastasis is frequently associated with bone-forming lesions, but the source of the osteoblastic lesions remains unclear. We show that the tumor-induced bone derives partly from tumor-associated endothelial cells that have undergone endothelial-to-osteoblast (EC-to-OSB) conversion. The tumor-associated osteoblasts in PCa bone metastasis specimens and patient-derived xenografts (PDXs) were found to co-express endothelial marker Tie-2. BMP4, identified in PDX-conditione ...[more]
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