Ontology highlight
ABSTRACT:
SUBMITTER: Marie L
PROVIDER: S-EPMC5512693 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Marie Léa L Rapisarda Chiara C Morales Violette V Bergé Mathieu M Perry Thomas T Soulet Anne-Lise AL Gruget Clémence C Remaut Han H Fronzes Rémi R Polard Patrice P
Nature communications 20170531
Homologous recombination (HR) is a central process of genome biology driven by a conserved recombinase, which catalyses the pairing of single-stranded DNA (ssDNA) with double-stranded DNA to generate a D-loop intermediate. Bacterial RadA is a conserved HR effector acting with RecA recombinase to promote ssDNA integration. The mechanism of this RadA-mediated assistance to RecA is unknown. Here, we report functional and structural analyses of RadA from the human pathogen Streptococcus pneumoniae. ...[more]