Ontology highlight
ABSTRACT:
SUBMITTER: Miles B
PROVIDER: S-EPMC5512733 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Miles Brett B Safran Howard P HP Monk Bradley J BJ
Gynecologic oncology research and practice 20170714
Survival of patients with advanced, recurrent, or metastatic human papillomavirus (HPV)-associated cancer is suboptimal despite the availability of various treatment modalities. The recently developed bacterial vector <i>Listeria monocytogenes</i> (<i>Lm</i>) activates innate and adaptive immune responses and is expected to offer immunologic advantages. Axalimogene filolisbac (AXAL or ADXS11-001) is a novel immunotherapeutic based on the live, irreversibly attenuated <i>Lm</i> fused to the nonhe ...[more]