Ontology highlight
ABSTRACT:
SUBMITTER: Losing P
PROVIDER: S-EPMC5513048 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Lösing Pascal P Niturad Cristina Elena CE Harrer Merle M Reckendorf Christopher Meyer Zu CMZ Schatz Theresa T Sinske Daniela D Lerche Holger H Maljevic Snezana S Knöll Bernd B
Molecular brain 20170717 1
A hallmark of temporal lobe epilepsy (TLE) is hippocampal neuronal demise and aberrant mossy fiber sprouting. In addition, unrestrained neuronal activity in TLE patients induces gene expression including immediate early genes (IEGs) such as Fos and Egr1.We employed the mouse pilocarpine model to analyze the transcription factor (TF) serum response factor (SRF) in epileptogenesis, seizure induced histopathology and IEG induction. SRF is a neuronal activity regulated TF stimulating IEG expression ...[more]