Severity of acute gastrointestinal injury grade is a predictor of all-cause mortality in critically ill patients: a multicenter, prospective, observational study.
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ABSTRACT: Background
In 2012, the European Society of Intensive Care Medicine proposed a definition for acute gastrointestinal injury (AGI) based on current medical evidence and expert opinion. The aim of the present study was to evaluate the feasibility of using the current AGI grading system and to investigate the association between AGI severity grades with clinical outcome in critically ill patients.Methods
Adult patients at 14 general intensive care units (ICUs) with an expected ICU stay ?24 h were prospectively studied. The AGI grade was assessed daily on the basis of gastrointestinal (GI) symptoms, intra-abdominal pressures, and feeding intolerance (FI) in the first week of admission to the ICU.Results
Among the 550 patients enrolled, 456 patients (82.9%) received mechanical ventilation, and 470 patients were identified for AGI. The distribution of the global AGI grade was 24.5% with grade I, 49.4% with grade II, 20.6% with grade III, and 5.5% with grade IV. AGI grading was positively correlated with 28- and 60-day mortality (P?2?=?41.9 vs. 52.2, P?=?0.007).Conclusions
The AGI grading scheme is useful for identifying the severity of GI dysfunction and could be used as a predictor of impaired outcomes. In addition, these results support the hypothesis that persistent FI within the first week of ICU stay is an independent determinant for mortality.Trial registration
Chinese Clinical Trial Registry identifier: ChiCTR-OCS-13003824 . Registered on 29 September 2013.
SUBMITTER: Hu B
PROVIDER: S-EPMC5513140 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Severity of acute gastrointestinal injury grade is a predictor of all-cause mortality in critically ill patients: a multicenter, prospective, observational study.
Hu Bangchuan B Sun Renhua R Wu Aiping A Ni Yin Y Liu Jingquan J Guo Feng F Ying Lijun L Ge Guoping G Ding Aijun A Shi Yunchao Y Liu Changwen C Xu Lei L Jiang Ronglin R Lu Jun J Lin Ronghai R Zhu Yannan Y Wu Weidong W Xie Bo B
Critical care (London, England) 20170714 1
<h4>Background</h4>In 2012, the European Society of Intensive Care Medicine proposed a definition for acute gastrointestinal injury (AGI) based on current medical evidence and expert opinion. The aim of the present study was to evaluate the feasibility of using the current AGI grading system and to investigate the association between AGI severity grades with clinical outcome in critically ill patients.<h4>Methods</h4>Adult patients at 14 general intensive care units (ICUs) with an expected ICU s ...[more]
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