Dataset Information

Patterns of care of brain tumor-related epilepsy. A cohort study done in Italian Epilepsy Center.

ABSTRACT: Epilepsy is the most common comorbidity in patients with brain tumors.

Study aims

To define characteristics of brain tumor-related epilepsy (BTRE) patients and identify patterns of care. Nationwide, multicenter retrospective cohort study. Medical records of BTRE patients seen from 1/1/2010 to 12/31/2011, followed for at least one month were examined. Information included age, sex, tumor type/treatments, epilepsy characteristics, antiepileptic drugs (AEDs). Time to modify first AED due to inefficacy and/or toxicity was assessed with the Kaplan-Meier method and Cox proportional hazard models were used to identify predictors of treatment outcome. Enrolled were 808 patients (447 men, 361 women) from 26 epilepsy centers. Follow-up ranged 1 to 423 months (median 18 months). 732 patients underwent surgery, 483 chemotherapy (CT), 508 radiotherapy. All patients were treated with AEDs. Levetiracetam was the most common drug. 377 patients (46.7%) were still on first drug at end of follow-up, 338 (41.8%) needed treatment modifications (uncontrolled seizures, 229; side effects, 101; poor compliance, 22). Treatment discontinuation for lack of efficacy was associated with younger age, chemotherapy, and center with <20 cases. Treatment discontinuation for side effects was associated with female sex, enzyme-inducing drugs and center with > 20 cases. About one-half of patients with BTRE were on first AED at end of follow-up. Levetiracetam was the most common drug. A non enzyme-inducing AED was followed by a lower risk of drug discontinuation for SE.

SUBMITTER: Maschio M

PROVIDER: S-EPMC5513411 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Patterns of care of brain tumor-related epilepsy. A cohort study done in Italian Epilepsy Center.

Maschio Marta M Beghi Ettore E Casazza Marina M L MML Colicchio Gabriella G Costa Cinzia C Banfi Paola P Quadri Stefano S Aloisi Paolo P Giallonardo Anna Teresa AT Buttinelli Carla C Pauletto Giada G Striano Salvatore S Salmaggi Andrea A Terenzi Riccardo R Daniele Ornella O Crichiutti Giovanni G Paladin Francesco F Rossi Rosario R Prato Giulia G Vigevano Federico F De Simone Roberto R Ricci Federica F Saladini Marina M Monti Fabrizio F Casellato Susanna S Zanoni Tiziano T Giannarelli Diana D Avanzini Giuliano G Aguglia Umberto U

PloS one 20170717 7

Epilepsy is the most common comorbidity in patients with brain tumors.<h4>Study aims</h4>To define characteristics of brain tumor-related epilepsy (BTRE) patients and identify patterns of care. Nationwide, multicenter retrospective cohort study. Medical records of BTRE patients seen from 1/1/2010 to 12/31/2011, followed for at least one month were examined. Information included age, sex, tumor type/treatments, epilepsy characteristics, antiepileptic drugs (AEDs). Time to modify first AED due to ...[more]

PMID: 28715490

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Dataset Information

Patterns of care of brain tumor-related epilepsy. A cohort study done in Italian Epilepsy Center.

Study aims

Publications

Patterns of care of brain tumor-related epilepsy. A cohort study done in Italian Epilepsy Center.

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