Ontology highlight
ABSTRACT:
SUBMITTER: Ran L
PROVIDER: S-EPMC5513719 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Ran Leili L Murphy Devan D Sher Jessica J Cao Zhen Z Wang Shangqian S Walczak Edward E Guan Youxin Y Xie Yuanyuan Y Shukla Shipra S Zhan Yu Y Antonescu Cristina R CR Chen Yu Y Chi Ping P
Cancer research 20170524 14
Gastrointestinal stromal tumor (GIST) is the most common subtype of sarcoma. Despite clinical advances in the treatment of <i>KIT/PDGFRA</i>-mutant GIST, similar progress against <i>KIT/PDGFRA</i> wild-type GIST, including mutant BRAF-driven tumors, has been limited by a lack of model systems. ETV1 is a master regulator in the intestinal cells of Cajal (ICC), thought to be the cells of origin of GIST. Here, we present a model in which the ETV1 promoter is used to specifically and inducibly drive ...[more]