Ontology highlight
ABSTRACT:
SUBMITTER: Jones M
PROVIDER: S-EPMC5513743 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Journal of medical virology 20170523 9
SB 9200 is a novel, first-in-class oral modulator of innate immunity that is believed to act via the activation of the RIG-I and NOD2 pathways. SB 9200 has broad-spectrum antiviral activity against RNA viruses including hepatitis C virus (HCV), norovirus, respiratory syncytial virus, and influenza and has demonstrated activity against hepatitis B virus (HBV) in vitro and in vivo. In phase I clinical trials in chronically infected HCV patients, SB 9200 has been shown to reduce HCV RNA by up to 1. ...[more]