Ontology highlight
ABSTRACT:
SUBMITTER: Anisenko AN
PROVIDER: S-EPMC5514147 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Anisenko Andrey N AN Knyazhanskaya Ekaterina S ES Zalevsky Artur O AO Agapkina Julia Yu JY Sizov Aleksander I AI Zatsepin Timofey S TS Gottikh Marina B MB
Scientific reports 20170717 1
Human Ku70/Ku80 protein is known to influence HIV-1 replication. One of the possible reasons may be the protection of integrase from proteasomal degradation by Ku70 subunit. We demonstrated that recombinant HIV-1 integrase and Ku70 form a stable complex, while no interaction of Ku70 with integrase from prototype foamy virus was observed. By analyzing protein subdomains we determined two binding sites in the structure of both Ku70 and integrase: the 51-160 a.a. region of integrase interacts with ...[more]