Ontology highlight
ABSTRACT:
SUBMITTER: Hosaka Y
PROVIDER: S-EPMC5514405 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
EBioMedicine 20170608
Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150<sup>Glued</sup>, is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra. However, the molecular relationship between p150<sup>Glued</sup> and TDP-43 is largely unknown. Here, we report that a reduction in TDP-43 protein levels alleviates the synaptic defects of neurons expressing the Perry mutant p150<sup>G50R</sup> in Drosophila. Dopaminergic expression of p150 ...[more]