CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target: Role of CPSF6 in Breast Cancer.
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ABSTRACT:
SUBMITTER: Binothman N
PROVIDER: S-EPMC5514498 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
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CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target: Role of CPSF6 in Breast Cancer.
Binothman Najat N Hachim Ibrahim Y IY Lebrun Jean-Jacques JJ Ali Suhad S
EBioMedicine 20170624
Breast cancer represents a major health challenge. The majority of breast cancer deaths are due to cancer progression/recurrence for which no efficient therapies exist. Aggressive breast cancers are characterized by loss of cellular differentiation. Defining molecular mechanisms/targets contributing to cancer aggressiveness is needed to guide the design of new screening and targeted treatments. Here, we describe a novel tumor promoting function for the Cleavage and Polyadenylation Factor-6 (CPSF ...[more]
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