Ontology highlight
ABSTRACT:
SUBMITTER: Dahl JU
PROVIDER: S-EPMC5514548 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Dahl Jan-Ulrik JU Gray Michael J MJ Bazopoulou Daphne D Beaufay Francois F Lempart Justine J Koenigsknecht Mark J MJ Wang Ying Y Baker Jason R JR Hasler William L WL Young Vincent B VB Sun Duxin D Jakob Ursula U
Nature microbiology 20170123
Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that mesalamine treatment rapidly decreases polyphosphate levels in diverse bacteria, including members of the human gut microbiome. This decrease sensitizes bacteria towards oxidative stress, reduces colonization and attenuates persister cell and biofilm formation, suggesting that mesalamine aids in diminishing the capacity of bacteria to persist with ...[more]