Ontology highlight
ABSTRACT:
SUBMITTER: Mollinari C
PROVIDER: S-EPMC551472 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Mollinari Cristiana C Kleman Jean-Philippe JP Saoudi Yasmina Y Jablonski Sandra A SA Perard Julien J Yen Tim J TJ Margolis Robert L RL
Molecular biology of the cell 20041222 3
The temporal and spatial regulation of cytokinesis requires an interaction between the anaphase mitotic spindle and the cell cortex. However, the relative roles of the spindle asters or the central spindle bundle are not clear in mammalian cells. The central spindle normally serves as a platform to localize key regulators of cell cleavage, including passenger proteins. Using time-lapse and immunofluorescence analysis, we have addressed the consequences of eliminating the central spindle by ablat ...[more]