Evolution of immune chemoreceptors into sensors of the outside world.
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ABSTRACT:
SUBMITTER: Dietschi Q
PROVIDER: S-EPMC5514743 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Evolution of immune chemoreceptors into sensors of the outside world.
Dietschi Quentin Q Tuberosa Joël J Rösingh Lone L Loichot Gregory G Ruedi Manuel M Carleton Alan A Rodriguez Ivan I
Proceedings of the National Academy of Sciences of the United States of America 20170626 28
Changes in gene expression patterns represent an essential source of evolutionary innovation. A striking case of neofunctionalization is the acquisition of neuronal specificity by immune formyl peptide receptors (Fprs). In mammals, Fprs are expressed by immune cells, where they detect pathogenic and inflammatory chemical cues. In rodents, these receptors are also expressed by sensory neurons of the vomeronasal organ, an olfactory structure mediating innate avoidance behaviors. Here we show that ...[more]
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