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Hippocampal dentation: Structural variation and its association with episodic memory in healthy adults.


ABSTRACT: While the hippocampus has long been identified as a structure integral to memory, the relationship between morphology and function has yet to be fully explained. We present an analysis of hippocampal dentation, a morphological feature previously unexplored in regard to its relationship with episodic memory. "Hippocampal dentation" in this case refers to surface convolutions, primarily present in the CA1/subiculum on the inferior aspect of the hippocampus. Hippocampal dentation was visualized using ultra-high resolution structural MRI and evaluated using a novel visual rating scale. The degree of hippocampal dentation was found to vary considerably across individuals, and was positively associated with verbal memory recall and visual memory recognition in a sample of 22 healthy adults. This study is the first to characterize the variation in hippocampal dentation in a healthy cohort and to demonstrate its association with aspects of episodic memory.

SUBMITTER: Fleming Beattie J 

PROVIDER: S-EPMC5514849 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Hippocampal dentation: Structural variation and its association with episodic memory in healthy adults.

Fleming Beattie Julia J   Martin Roy C RC   Kana Rajesh K RK   Deshpande Hrishikesh H   Lee Seongtaek S   Curé Joel J   Ver Hoef Lawrence L  

Neuropsychologia 20170501


While the hippocampus has long been identified as a structure integral to memory, the relationship between morphology and function has yet to be fully explained. We present an analysis of hippocampal dentation, a morphological feature previously unexplored in regard to its relationship with episodic memory. "Hippocampal dentation" in this case refers to surface convolutions, primarily present in the CA1/subiculum on the inferior aspect of the hippocampus. Hippocampal dentation was visualized usi  ...[more]

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