Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target.
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ABSTRACT:
SUBMITTER: Wen Y
PROVIDER: S-EPMC5514966 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target.
Wen Yiping Y Cai Jing J Hou Yaya Y Huang Zaiju Z Wang Zehua Z
Oncotarget 20170601 23
Epigenetic modifications in cancer stem cells largely result in phenotypic and functional heterogeneity in many solid tumors. Increasing evidence indicates that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of Polycomb repressor complex 2, is highly expressed in cancer stem cells of numerous malignant tumors and has a critical function in cancer stem cell expansion and maintenance. Here, we review up-to-date information regarding EZH2 expression patterns, functions, and molecular mec ...[more]
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