Ontology highlight
ABSTRACT:
SUBMITTER: Salminen LE
PROVIDER: S-EPMC5515475 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Salminen Lauren E LE Schofield Peter R PR Pierce Kerrie D KD Bruce Steven E SE Griffin Michael G MG Tate David F DF Cabeen Ryan P RP Laidlaw David H DH Conturo Thomas E TE Bolzenius Jacob D JD Paul Robert H RH
Behavioural brain research 20170427
Oxidative stress is a key mechanism of the aging process that can cause damage to brain white matter and cognitive functions. Polymorphisms in the superoxide dismutase 2 (SOD2) and catalase (CAT) genes have been associated with abnormalities in antioxidant enzyme activity in the aging brain, suggesting a risk for enhanced oxidative damage to white matter and cognition among older individuals with these genetic variants. The present study compared differences in white matter microstructure and co ...[more]