Ontology highlight
ABSTRACT:
SUBMITTER: Middleton DR
PROVIDER: S-EPMC5515494 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20170531 2
Most pathogenic bacteria express surface carbohydrates called capsular polysaccharides (CPSs). CPSs are important vaccine targets because they are easily accessible and recognizable by the immune system. However, CPS-specific adaptive humoral immune responses can only be achieved by the covalent conjugation of CPSs with carrier proteins to produce glycoconjugate vaccines. We previously described a mechanism by which a model glycoconjugate vaccine can activate the adaptive immune system and demon ...[more]