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Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes.

ABSTRACT: We report the first enantioselective Rh-catalyzed Markovnikov hydroboration of unactivated terminal alkenes. Using a novel sp²-sp³ hybridized diboron reagent and water as a proton source, a broad range of alkenes undergo hydroboration to provide secondary boronic esters with high regio- and enantiocontrol.

SUBMITTER: Smith JR

PROVIDER: S-EPMC5515510 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes.

Smith James R JR Collins Beatrice S L BSL Hesse Matthew J MJ Graham Mark A MA Myers Eddie L EL Aggarwal Varinder K VK

Journal of the American Chemical Society 20170630 27

We report the first enantioselective Rh-catalyzed Markovnikov hydroboration of unactivated terminal alkenes. Using a novel sp<sup>2</sup>-sp<sup>3</sup> hybridized diboron reagent and water as a proton source, a broad range of alkenes undergo hydroboration to provide secondary boronic esters with high regio- and enantiocontrol. ...[more]

PMID: 28665124

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