Fresh or Cryopreserved CD34⁺-Selected Mobilized Peripheral Blood Stem and Progenitor Cells for the Treatment of Poor Graft Function after Allogeneic Hematopoietic Cell Transplantation.

ABSTRACT: CD34⁺-selected stem cell boost (SCB) without conditioning has recently been utilized for poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation with promising results. Unfortunately, many patients have been unable to receive the boost infusion as their donors were unwilling or unable to undergo an additional stem cell collection. Therefore, we conducted this study utilizing either fresh or cryopreserved peripheral blood stem cell products to create CD34⁺-selected boost infusions for the treatment of PGF. Additionally, to explore relationship of CD34⁺ dose and response, we included a cohort of donors mobilized with plerixafor in addition to the standard granulocyte colony-stimulating factor (G-CSF). Twenty-six patients with PGF we

SUBMITTER: Ghobadi A 

PROVIDER: S-EPMC5515540 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature