Intracellular Survival of Staphylococcus aureus in Endothelial Cells: A Matter of Growth or Persistence.

ABSTRACT: The Gram-positive human pathogen Staphylococcus aureus is a leading cause of severe bacterial infections. Recent studies have shown that various cell types could readily internalize S. aureus and infected cells have been proposed to serve as vehicle for the systemic dissemination of the pathogen. Here we focused on the intracellular behavior of the Community-Associated Methicillin-Resistant S. aureus strain USA300. Supporting earlier observations, we found that wild-type S. aureus strain USA300 persisted for longer period within endothelial cells than within macrophages and that a mutant displaying the small colony variant phenotype (ΔhemDBL) had increased intracellular persistence. Time-lapse microscopy revealed that initial persistence of wild-type bact

SUBMITTER: Rollin G 

PROVIDER: S-EPMC5515828 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature