Ontology highlight
ABSTRACT:
SUBMITTER: Hu X
PROVIDER: S-EPMC5516189 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Hu Xiao X Hang Yaming Y Cui Yue Y Zhang Jie J Liu Shifang S Seddighzadeh Ali A Deykin Aaron A Nestorov Ivan I
Journal of clinical pharmacology 20170410 8
Peginterferon beta-1a reduced annualized relapse rate as compared with placebo and was approved to treat multiple sclerosis patients. A population pharmacokinetic and an exposure-efficacy model were developed to establish the quantitative relationship between pharmacokinetics and annualized relapse rate. The pharmacokinetics was well described by a 1-compartment model with first-order absorption and linear elimination kinetics. Body mass index was the most significant covariate that impacted bot ...[more]