Ontology highlight
ABSTRACT:
SUBMITTER: Slijepcevic D
PROVIDER: S-EPMC5516419 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Slijepcevic Davor D van de Graaf Stan F J SF
Digestive diseases (Basel, Switzerland) 20170301 3
<h4>Background</h4>Bile acids are potent signaling molecules that regulate glucose, lipid and energy homeostasis predominantly via the bile acid receptors farnesoid X receptor (FXR) and transmembrane G protein-coupled receptor 5 (TGR5). The sodium taurocholate cotransporting polypeptide (NTCP) and the apical sodium dependent bile acid transporter (ASBT) ensure an effective circulation of (conjugated) bile acids. The modulation of these transport proteins affects bile acid localization, dynamics ...[more]