Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki Y
PROVIDER: S-EPMC5516478 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Suzuki Yuki Y Saito Yohei Y Goto Masuo M Newman David J DJ O'Keefe Barry R BR Lee Kuo-Hsiung KH Nakagawa-Goto Kyoko K
Journal of natural products 20170118 1
Twelve benzylisoquinoline alkaloids, including pavine and phenanthroindolizidine types, were isolated from a MeOH/CH<sub>2</sub>Cl<sub>2</sub> extract of Cryptocarya laevigata (stem bark) through bioactivity-guided fractionation for antitumor effects. Selected compounds were evaluated for antiproliferative activity against five human tumor cell lines, including a multidrug-resistant subline. Since more common 2,3,8,9-tetrasubstituted pavine alkaloids, such as crychine (3), exhibit very mild or n ...[more]