Ontology highlight
ABSTRACT:
SUBMITTER: Mutter RW
PROVIDER: S-EPMC5516531 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Mutter Robert W RW Riaz Nadeem N Ng Charlotte Ky CK Delsite Rob R Piscuoglio Salvatore S Edelweiss Marcia M Martelotto Luciano G LG Sakr Rita A RA King Tari A TA Giri Dilip D DD Drobnjak Maria M Brogi Edi E Bindra Ranjit R Bernheim Giana G Lim Raymond S RS Blecua Pedro P Desrichard Alexis A Higginson Dan D Towers Russell R Jiang Ruomu R Lee William W Weigelt Britta B Reis-Filho Jorge S JS Powell Simon N SN
The Journal of pathology 20170427 2
Homologous recombination (HR) DNA repair-deficient (HRD) breast cancers have been shown to be sensitive to DNA repair targeted therapies. Burgeoning evidence suggests that sporadic breast cancers, lacking germline BRCA1/BRCA2 mutations, may also be HRD. We developed a functional ex vivo RAD51-based test to identify HRD primary breast cancers. An integrated approach examining methylation, gene expression, and whole-exome sequencing was employed to ascertain the aetiology of HRD. Functional HRD br ...[more]