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Picture free recall performance linked to the brain's structural connectome.


ABSTRACT: INTRODUCTION:Memory functions are highly variable between healthy humans. The neural correlates of this variability remain largely unknown. METHODS:Here, we investigated how differences in free recall performance are associated with DTI-based properties of the brain's structural connectome and with grey matter volumes in 664 healthy young individuals tested in the same MR scanner. RESULTS:Global structural connectivity, but not overall or regional grey matter volumes, positively correlated with recall performance. Moreover, a set of 22 inter-regional connections, including some with no previously reported relation to human memory, such as the connection between the temporal pole and the nucleus accumbens, explained 7.8% of phenotypic variance. CONCLUSIONS:In conclusion, this large-scale study indicates that individual memory performance is associated with the level of structural brain connectivity.

SUBMITTER: Coynel D 

PROVIDER: S-EPMC5516597 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Picture free recall performance linked to the brain's structural connectome.

Coynel David D   Gschwind Leo L   Fastenrath Matthias M   Freytag Virginie V   Milnik Annette A   Spalek Klara K   Papassotiropoulos Andreas A   de Quervain Dominique J-F DJ  

Brain and behavior 20170523 7


<h4>Introduction</h4>Memory functions are highly variable between healthy humans. The neural correlates of this variability remain largely unknown.<h4>Methods</h4>Here, we investigated how differences in free recall performance are associated with DTI-based properties of the brain's structural connectome and with grey matter volumes in 664 healthy young individuals tested in the same MR scanner.<h4>Results</h4>Global structural connectivity, but not overall or regional grey matter volumes, posit  ...[more]

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