Manganese-enhanced magnetic resonance imaging combined with electrophysiology in the evaluation of visual pathway in experimental rat models with monocular blindness.

ABSTRACT:

Purpose

Our study aimed to explore the feasibility of manganese-enhanced magnetic resonance imaging (MEMRI) combined with visual evoked potentials (VEP) and auditory evoked visual cortex responses (AVR) in evaluating for the establishment of visual/auditory compensatory pathways after monocular blindness.

Materials and methods

A total of 14 healthy neonatal male Sprague-Dawley rats were randomly divided into two groups (n = 7 for Groups A and B). Right optic nerve (ON) transection was performed on the 7 rats of Group A to obtain a monocularly blind model, and the 7 rats of Group B were chosen as the control group. Four months later, 400 mmol MnCl₂ was injected into the left eye in both groups via intravitreal injection. The changes in the visual pathways pr

SUBMITTER: Tang Z 

PROVIDER: S-EPMC5516605 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature