Ontology highlight
ABSTRACT:
SUBMITTER: Maiuri AR
PROVIDER: S-EPMC5516887 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Maiuri Ashley R AR Peng Michael M Podicheti Ram R Sriramkumar Shruthi S Kamplain Caitlin M CM Rusch Douglas B DB DeStefano Shields Christina E CE Sears Cynthia L CL O'Hagan Heather M HM
Cancer research 20170518 13
Aberrant silencing of genes by DNA methylation contributes to cancer, yet how this process is initiated remains unclear. Using a murine model of inflammation-induced tumorigenesis, we tested the hypothesis that inflammation promotes recruitment of epigenetic proteins to chromatin, initiating methylation and gene silencing in tumors. Compared with normal epithelium and noninflammation-induced tumors, inflammation-induced tumors gained DNA methylation at CpG islands, some of which are associated w ...[more]