Migration Phenotype of Brain-Cancer Cells Predicts Patient Outcomes.
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ABSTRACT:
SUBMITTER: Smith CL
PROVIDER: S-EPMC5517094 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Migration Phenotype of Brain-Cancer Cells Predicts Patient Outcomes.
Smith Chris L CL Kilic Onur O Schiapparelli Paula P Guerrero-Cazares Hugo H Kim Deok-Ho DH Sedora-Roman Neda I NI Gupta Saksham S O'Donnell Thomas T Chaichana Kaisorn L KL Rodriguez Fausto J FJ Abbadi Sara S Park JinSeok J Quiñones-Hinojosa Alfredo A Levchenko Andre A
Cell reports 20160609 12
Glioblastoma multiforme is a heterogeneous and infiltrative cancer with dismal prognosis. Studying the migratory behavior of tumor-derived cell populations can be informative, but it places a high premium on the precision of in vitro methods and the relevance of in vivo conditions. In particular, the analysis of 2D cell migration may not reflect invasion into 3D extracellular matrices in vivo. Here, we describe a method that allows time-resolved studies of primary cell migration with single-cell ...[more]
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