Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC5517417 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Wang Qi Q Alshaker Heba H Böhler Torsten T Srivats Shyam S Chao Yimin Y Cooper Colin C Pchejetski Dmitri D
Scientific reports 20170719 1
Many prostate cancers relapse after initial chemotherapy treatment. Combining molecular and chemotherapy together with encapsulation of drugs in nanocarriers provides effective drug delivery and toxicity reduction. We developed core shell lipid-polymer hybrid nanoparticles (CSLPHNPs) with poly (lactic-co-glycolic acid) (PLGA) core and lipid layer containing docetaxel and clinically used inhibitor of sphingosine kinase 1 (SK1) FTY720 (fingolimod). We show for the first time that FTY720 (both free ...[more]