Bursting dynamics in the normal and failing hearts.
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ABSTRACT:
SUBMITTER: Bondarenko VE
PROVIDER: S-EPMC5517618 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Bursting dynamics in the normal and failing hearts.
Bondarenko Vladimir E VE Shilnikov Andrey L AL
Scientific reports 20170719 1
A failing heart differs from healthy hearts by an array of symptomatic characteristics, including impaired Ca<sup>2+</sup> transients, upregulation of Na<sup>+</sup>/Ca<sup>2+</sup> exchanger function, reduction of Ca<sup>2+</sup> uptake to sarcoplasmic reticulum, reduced K<sup>+</sup> currents, and increased propensity to arrhythmias. While significant efforts have been made in both experimental studies and model development to display the causes of heart failure, the full process of deteriorat ...[more]
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