Ontology highlight
ABSTRACT:
SUBMITTER: Gjoen JE
PROVIDER: S-EPMC5517635 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Gjøen John Espen JE Jenum Synne S Sivakumaran Dhanasekaran D Mukherjee Aparna A Macaden Ragini R Kabra Sushil K SK Lodha Rakesh R Ottenhoff Tom H M THM Haks Marielle C MC Doherty Timothy Mark TM Ritz Christian C Grewal Harleen M S HMS
Scientific reports 20170719 1
Pediatric tuberculosis (TB) is challenging to diagnose, confirmed by growth of Mycobacterium tuberculosis at best in 40% of cases. The WHO has assigned high priority to the development of non-sputum diagnostic tools. We therefore sought to identify transcriptional signatures in whole blood of Indian children, capable of discriminating intra-thoracic TB disease from other symptomatic illnesses. We investigated the expression of 198 genes in a training set, comprising 47 TB cases (19 definite/28 p ...[more]