Ontology highlight
ABSTRACT:
SUBMITTER: Consolim-Colombo FM
PROVIDER: S-EPMC5518569 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Consolim-Colombo Fernanda M FM Sangaleti Carine T CT Costa Fernando O FO Morais Tercio L TL Lopes Heno F HF Motta Josiane M JM Irigoyen Maria C MC Bortoloto Luiz A LA Rochitte Carlos Eduardo CE Harris Yael Tobi YT Satapathy Sanjaya K SK Olofsson Peder S PS Akerman Meredith M Chavan Sangeeta S SS MacKay Meggan M Barnaby Douglas P DP Lesser Martin L ML Roth Jesse J Tracey Kevin J KJ Pavlov Valentin A VA
JCI insight 20170720 14
<h4>Background</h4>Metabolic syndrome (MetS) is an obesity-driven condition of pandemic proportions that increases the risk of type 2 diabetes and cardiovascular disease. Pathophysiological mechanisms are poorly understood, though inflammation has been implicated in MetS pathogenesis. The aim of this study was to assess the effects of galantamine, a centrally acting acetylcholinesterase inhibitor with antiinflammatory properties, on markers of inflammation implicated in insulin resistance and ca ...[more]