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Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain-->.

ABSTRACT: Two new compounds, named lyciumlignan D (1) and lyciumphenyl propanoid A (2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3-9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 ?mol/L.

SUBMITTER: Yang Y

PROVIDER: S-EPMC5518643 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain-->.

Yang Yanan Y An Yawen Y Wang Wei W Du Ning N Zhang Jinghua J Feng Ziming Z Jiang Jianshuang J Zhang Peicheng P

Acta pharmaceutica Sinica. B 20170503 4

Two new compounds, named lyciumlignan D (1) and lyciumphenyl propanoid A (2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3-9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited ...[more]

PMID: 28752035

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Project description:The root bark of Zizyphus nummularia (Rhamnaceae) is traditionally used as an anti-inflammatory agent. The current study aimed to explore the anti-inflammatory activity (in vivo) of a crude ethanolic extract (EE) and the pure identified octadecahydro-picene-2,3,14,15-tetranone (IC) in the root bark of Z. nummularia. IC was further subjected to suitable in vitro and in silico studies to find out the mechanistic pharmacology.EE (100 and 200 mg/kg, p.o.) and (IC) (400 and 600 ?g/kg, p.o.) were subjected to in vivo anti-inflammatory assays to evaluate the anti-inflammatory activity and predict the probable mechanism(s) of action. Suitable acute (carrageenan-induced paw edema, arachidonic acid-induced ear edema, xylene-induced ear edema) and chronic (cotton pellet granuloma) models were employed to investigate in vivo the anti-inflammatory activity. Based on in vivo observation, IC was further subjected to in vitro assays to estimate the inhibition of nitric oxide (NO), prostaglandin-E2 (PGE-2) and tumor necrosis factor-? (TNF-?) production in PBS stimulated RAW 264.7 cells. Based on the observation of in vitro studies, finally, ADME prediction and molecular docking studies of IC were performed for better understanding of interaction of IC with TNF-?.Oral administration of EE (100 and 200 mg/kg) exhibited significant inhibition of carrageenan (p?<?0.05) and arachidonic acid (p?<?0.05) induced oedema, and the reduced the granuloma tissue formation (p?<?0.05) in experimental mice. IC (400 and 600 ?g/kg, p.o.) exhibited significant (p?<?0.01) inhibition of carrageenan, xylene and arachidonic acid-induced edema, and reduced the granuloma tissue formation. In in vitro assays, IC caused a concentration-dependent inhibition of LPS stimulated NO (up to?~?67.4% at 50 ?M) and TNF-? (~84.5% at 50 ?M) production. However, the PGE-2 inhibition did not follow dose dependent pattern. Based on in vitro observations, the molecular docking has been performed on the basis of interaction with TNF-?. In in silico studies, it was observed that IC showed hydrogen bonding with GLN 47 amino acid residue of TNF-? protein.IC possibly produces anti-inflammatory activity through inhibition of TNF-? and NO production.

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Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain-->.

Publications

Nine compounds from the root bark of <i>Lycium chinense</i> and their anti-inflammatory activitieslammatory activitiesretain-->.

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