Ontology highlight
ABSTRACT:
SUBMITTER: Osman H
PROVIDER: S-EPMC5518655 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Osman Hasnah H Idris Nor Hashima NH Kamarulzaman Ezatul Ezleen EE Wahab Habibah A HA Hassan Mohd Zaheen MZ
Acta pharmaceutica Sinica. B 20170504 4
Dengue is a severe mosquito-borne viral infection causing half a million deaths annually. Dengue virus NS2B/NS3 protease is a validated target for anti-dengue drug design. A series of hitherto unreported 3,5-bis(arylidene)-4-piperidones analogues <b>4a</b>-<b>4j</b> were synthesized and screened <i>in silico</i> against DENV2 NS2B/NS3 protease to elucidate their binding mechanism and orientation around the active sites. Results were validated through an <i>in vitro</i> DENV2 NS2B/NS3 protease as ...[more]