Cation-Selective Channel Regulated by Anions According to Their Hofmeister Ranking.
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ABSTRACT:
SUBMITTER: Gurnev PA
PROVIDER: S-EPMC5518747 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Cation-Selective Channel Regulated by Anions According to Their Hofmeister Ranking.
Gurnev Philip A PA Roark Torri C TC Petrache Horia I HI Sodt Alexander J AJ Bezrukov Sergey M SM
Angewandte Chemie (International ed. in English) 20170215 13
Specificity of small ions, the Hofmeister ranking, is long-known and has many applications including medicine. Yet it evades consistent theoretical description. Here we study the effect of Hofmeister anions on gramicidin A channels in lipid membranes. Counterintuitively, we find that conductance of this perfectly cation-selective channel increases about two-fold in the H<sub>2</sub> PO<sub>4</sub><sup>-</sup> <Cl<sup>-</sup> ≈Br<sup>-</sup> ≈NO<sub>3</sub><sup>-</sup> <ClO<sub>4</sub><sup>-</sup ...[more]
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