Ontology highlight
ABSTRACT:
SUBMITTER: Matzaraki V
PROVIDER: S-EPMC5519064 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Matzaraki Vasiliki V Gresnigt Mark S MS Jaeger Martin M Ricaño-Ponce Isis I Johnson Melissa D MD Oosting Marije M Franke Lude L Withoff Sebo S Perfect John R JR Joosten Leo A B LAB Kullberg Bart Jan BJ van de Veerdonk Frank L FL Jonkers Iris I Li Yang Y Wijmenga Cisca C Netea Mihai G MG Kumar Vinod V
PloS one 20170720 7
Candidaemia is a bloodstream infection caused by Candida species that primarily affects specific groups of at-risk patients. Because only small candidaemia patient cohorts are available, classical genome wide association cannot be used to identify Candida susceptibility genes. Therefore, we have applied an integrative genomics approach to identify novel susceptibility genes and pathways for candidaemia. Candida-induced transcriptome changes in human primary leukocytes were assessed by RNA sequen ...[more]