Ontology highlight
ABSTRACT:
SUBMITTER: Norsworthy MW
PROVIDER: S-EPMC5519288 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Neuron 20170601 6
At least 30 types of retinal ganglion cells (RGCs) send distinct messages through the optic nerve to the brain. Available strategies of promoting axon regeneration act on only some of these types. Here we tested the hypothesis that overexpressing developmentally important transcription factors in adult RGCs could reprogram them to a "youthful" growth-competent state and promote regeneration of other types. From a screen of transcription factors, we identified Sox11 as one that could induce subst ...[more]