Ontology highlight
ABSTRACT:
SUBMITTER: Lake BB
PROVIDER: S-EPMC5519641 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Lake Blue B BB Codeluppi Simone S Yung Yun C YC Gao Derek D Chun Jerold J Kharchenko Peter V PV Linnarsson Sten S Zhang Kun K
Scientific reports 20170720 1
Significant heterogeneities in gene expression among individual cells are typically interrogated using single whole cell approaches. However, tissues that have highly interconnected processes, such as in the brain, present unique challenges. Single-nucleus RNA sequencing (SNS) has emerged as an alternative method of assessing a cell's transcriptome through the use of isolated nuclei. However, studies directly comparing expression data between nuclei and whole cells are lacking. Here, we have cha ...[more]