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Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus.


ABSTRACT: Extensive phytochemical investigation on the whole herbs of Delphinium anthriscifolium var. majus led to the identification of fourteen diterpenoid alkaloids, including three new C20-diterpenoid alkaloids (anthriscifolsines A-C, 1-3), six new C19-diterpenoid alkaloids (anthriscifolrines A-F, 4-9), and five know compounds (10-14). Among them, anthriscifolsine A represents a novel C20-diterpenoid alkaloid characterized by a seco C-ring. The structures of the isolated compounds were elucidated by extensive spectroscopic methods, including HR-ESI-MS, X-ray, and 1D and 2D NMR experiments. Bioactivity of compounds 3-6 was evaluated for their cytotoxicity against the MCF-7, HepG2 and H460 cancer cell lines.

SUBMITTER: Shan LH 

PROVIDER: S-EPMC5519776 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus.

Shan Lian-Hai LH   Zhang Ji-Fa JF   Gao Feng F   Huang Shuai S   Zhou Xian-Li XL  

Scientific reports 20170720 1


Extensive phytochemical investigation on the whole herbs of Delphinium anthriscifolium var. majus led to the identification of fourteen diterpenoid alkaloids, including three new C<sub>20</sub>-diterpenoid alkaloids (anthriscifolsines A-C, 1-3), six new C<sub>19</sub>-diterpenoid alkaloids (anthriscifolrines A-F, 4-9), and five know compounds (10-14). Among them, anthriscifolsine A represents a novel C<sub>20</sub>-diterpenoid alkaloid characterized by a seco C-ring. The structures of the isolat  ...[more]

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