Dataset Information

Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness.

ABSTRACT: To investigate the effects of heart rate (HR), left ventricular ejection time (LVET) and wave reflection on arterial stiffness as assessed by pulse wave velocity (PWV), a pulse wave propagation simulation system (PWPSim) based on the transmission line model of the arterial tree was developed and was applied to investigate pulse wave propagation. HR, LVET, arterial elastic modulus and peripheral resistance were increased from 60 to 100 beats per minute (bpm), 0.1 to 0.45?seconds, 0.5 to 1.5 times and 0.5 to 1.5 times of the normal value, respectively. Carotid-femoral PWV (cfPWV) and brachial-ankle PWV (baPWV) were calculated by intersecting tangent method (cfPWV_tan and baPWV_tan), maximum slope (cfPWV_max and baPWV_max), and using the Moens-Korteweg equation ([Formula: see text] and [Formula: see text]). Results showed cfPWV and baPWV increased significantly with arterial elastic modulus but did not increase with HR when using a constant elastic modulus. However there were significant LVET dependencies of cfPWV_tan and baPWV_tan (0.17?±?0.13 and 0.17?±?0.08?m/s per 50?ms), and low peripheral resistance dependencies of cfPWV_tan, cfPWV_max, baPWV_tan and baPWV_max (0.04?±?0.01, 0.06?±?0.04, 0.06?±?0.03 and 0.09?±?0.07?m/s per 10% peripheral resistance), respectively. This study demonstrated that LVET dominates the effect on calculated PWV compared to HR and peripheral resistance when arterial elastic modulus is constant.

SUBMITTER: Xiao H

PROVIDER: S-EPMC5519778 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness.

Xiao Hanguang H Butlin Mark M Tan Isabella I Avolio Alberto A

Scientific reports 20170720 1

To investigate the effects of heart rate (HR), left ventricular ejection time (LVET) and wave reflection on arterial stiffness as assessed by pulse wave velocity (PWV), a pulse wave propagation simulation system (PWPSim) based on the transmission line model of the arterial tree was developed and was applied to investigate pulse wave propagation. HR, LVET, arterial elastic modulus and peripheral resistance were increased from 60 to 100 beats per minute (bpm), 0.1 to 0.45 seconds, 0.5 to 1.5 times ...[more]

PMID: 28729696

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Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness.

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Effects of cardiac timing and peripheral resistance on measurement of pulse wave velocity for assessment of arterial stiffness.

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