Ontology highlight
ABSTRACT:
SUBMITTER: Aguilo N
PROVIDER: S-EPMC5519979 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Aguilo Nacho N Gonzalo-Asensio Jesus J Alvarez-Arguedas Samuel S Marinova Dessislava D Gomez Ana Belen AB Uranga Santiago S Spallek Ralf R Singh Mahavir M Audran Regine R Spertini François F Martin Carlos C
Nature communications 20170714
MTBVAC is a live-attenuated Mycobacterium tuberculosis vaccine, currently under clinical development, that contains the major antigens ESAT6 and CFP10. These antigens are absent from the current tuberculosis vaccine, BCG. Here we compare the protection induced by BCG and MTBVAC in several mouse strains that naturally express different MHC haplotypes differentially recognizing ESAT6 and CFP10. MTBVAC induces improved protection in C3H mice, the only of the three tested strains reactive to both ES ...[more]