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Seroepidemiology of enterovirus D68 infection in China.


ABSTRACT: Human enterovirus 68 (EV-D68) is a rarely reported virus that has been linked to respiratory disease. In recent years, reports about EV-D68 infection have markedly increased worldwide. However, the epidemiological features of this emerging infection are not well understood. To evaluate the emerging EV-D68 epidemic, we isolated the circulating viral strain and investigated the seroprevalence of neutralizing antibodies (NAbs) in Beijing between 2004 and 2011. We found that the titers of EV-D68 NAbs were generally low in all age groups in sampled populations in 2004 but significantly higher in 2009. From 2007 to 2011, the NAbs against EV-D68 significantly increased over time. These findings indicate that EV-D68 has spread widely in the Chinese population in recent years, although only a limited number of cases were reported.

SUBMITTER: Xiang Z 

PROVIDER: S-EPMC5520479 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Seroepidemiology of enterovirus D68 infection in China.

Xiang Zichun Z   Li Linlin L   Ren Lili L   Guo Li L   Xie Zhengde Z   Liu Chunyan C   Li Taisheng T   Luo Ming M   Paranhos-Baccalà Gláucia G   Xu Wenbo W   Wang Jianwei J  

Emerging microbes & infections 20170510 5


Human enterovirus 68 (EV-D68) is a rarely reported virus that has been linked to respiratory disease. In recent years, reports about EV-D68 infection have markedly increased worldwide. However, the epidemiological features of this emerging infection are not well understood. To evaluate the emerging EV-D68 epidemic, we isolated the circulating viral strain and investigated the seroprevalence of neutralizing antibodies (NAbs) in Beijing between 2004 and 2011. We found that the titers of EV-D68 NAb  ...[more]

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