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Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.

ABSTRACT: The natural tetracyclic schweinfurthins are potent and selective inhibitors of cell growth in the National Cancer Institute's 60-cell line screen. An interest in determination of their cellular or molecular target has inspired our efforts to prepare both the natural products and analogues. In this paper, chemical synthesis of analogues modified in different olefinic positions, and preliminary results from studies of their biological activity, are reported.

SUBMITTER: Ulrich NC

PROVIDER: S-EPMC5520629 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.

Ulrich Natalie C NC Kodet John G JG Mente Nolan R NR Kuder Craig H CH Beutler John A JA Hohl Raymond J RJ Wiemer David F DF

Bioorganic & medicinal chemistry 20100104 4

The natural tetracyclic schweinfurthins are potent and selective inhibitors of cell growth in the National Cancer Institute's 60-cell line screen. An interest in determination of their cellular or molecular target has inspired our efforts to prepare both the natural products and analogues. In this paper, chemical synthesis of analogues modified in different olefinic positions, and preliminary results from studies of their biological activity, are reported. ...[more]

PMID: 20116262

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